In order to find out the specific chromosomal abnormalities of the gastric adenocarcinoma in Korea, author investigated one primary and two cell lines of gastric cancer with G-banding technique. All tumor cells had clonal chromosomal
abnormalities
:
total 101 numerical and 25t structural karyotypic abnomalies were identified. The most prominent and recurring numerical abnormalities were trisomy 1, 2, 3, 6, 9, 10, 16, X and tetrasomy 1, 7, 9, 18, 20, 21 and recurrent structural abnormalities
were
del(1) (q32→qter), del(1)(p34→qter), del(3)(p25→qter), der(4)(4:1)(q32 : qter), del(10)(p13→pter), del(X)(p22).
The above results of wide variety of karyotyping in stomach cancer cells indicate that these are general due to secondary changes rather than primary changes specific to stomach cancer cells and also the break at bands 1p34, 2p24, 3p25, 4p14,
5p34,
6p11, 8p24, 11p15, 11p23 give rise to the deletion of cellular oncogenes fgr, src-2, N-myc, rafl, raf2, fms, K-rasl, myc, abl, H-rasl.
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